10 Best Calming Products For Cats 2025 in the United States

The TherapetMD Cat Calming Diffuser is a plug-in pheromone diffuser designed to reduce anxiety and stress in cats, especially in multi-cat households. It uses a natural, vet-recommended dual-pheromone formula that mimics facial and maternal cat pheromones, helping to significantly cut down behaviors like urine spraying and scratching. One of its strengths is the 700 sq ft coverage area, making it suitable for larger rooms or shared spaces.

The diffuser works continuously once plugged in, with each refill lasting about 30 days, so it’s convenient and requires minimal effort from owners. It’s fragrance-free and safe for cats, humans, and other pets, which is important for households with multiple animals or sensitive individuals. Many users report noticeable improvements in reducing hiding, fear, and tension between cats, making it helpful during stressful events like vet visits or introducing new pets. It may take a few days to see the calming effects, and the low-glow indicator light might be hard to notice in bright settings, though this doesn’t affect the diffuser’s function.

Some cats may respond differently depending on their individual preferences, so results can vary. This diffuser provides a gentle, chemical-free way to create a calmer environment for anxious or stressed cats without hassle, although patience is needed to observe the full benefits.

The Vetoquinol Zylkene Calming Supplement is designed to help small dogs and cats manage stress from situations like travel, vet visits, or loud noises. Its main calming ingredient, alpha-casozepine, comes from a milk protein, making it a natural option that avoids drowsiness or harsh side effects commonly seen in other calming products.

This supplement is lactose-free and gentle on sensitive stomachs, which is beneficial for cats with digestive sensitivities. The package contains capsules that you open and sprinkle over your pet’s food, making it straightforward to use daily. This daily routine can support behavioral issues and help your cat stay calm during stressful events.

With a solid positive rating from many users, Zylkene offers a safe, gentle, and easy-to-administer way to support your cat’s relaxation. Pet owners should monitor their cat’s response and ensure proper dosing.

The FELIWAY Optimum diffuser uses synthetic pheromones designed to mimic natural calming signals cats give each other, making it a drug-free and non-sedating option. This makes it a good fit for cat owners looking for a safe, gentle way to reduce stress-related behaviors like spraying, scratching, and fearfulness. It works continuously for up to 30 days per vial, covering about 700 square feet, which suits most home environments with one or two diffusers. It’s simple to use—just plug into an outlet with some open space around it for best effect—and designed specifically for cats, so it won’t affect people or other pets. Users report significant reductions in common stress behaviors, which supports its effectiveness.

Because it relies on pheromones, results can vary from cat to cat depending on individual preferences and sensitivity. The diffuser must be replaced every six months and only with official FELIWAY refills, which adds some ongoing cost and limits flexibility with third-party products. Placement matters, too; it shouldn’t be hidden behind furniture or near litter boxes to work well.

While some cats respond quickly, others might take longer or need additional calming support. FELIWAY Optimum is a trusted, veterinarian-recommended calming product best suited for cat owners who want a safe, easy-to-use, and steady way to ease their cat’s stress without medication, though it requires monthly maintenance and careful placement for best results.